Density differences between hybrid and nonhybrid particles in two adenovirus-simian virus 40 hybrid populations.
نویسندگان
چکیده
The adenovirus 7-simian virus 40 hybrid virus population E46(+) was subjected to fixed-angle equilibrium density gradient centrifugation in CsCl. A difference in buoyant density between the hybrid virion and its nonhybrid adenovirus 7 counterpart was noted, the hybrid virion possessing the lower buoyant density. This difference in buoyant density appeared to be accentuated in a population of adenovirus 2(+t7), a derivative of E46(+) in which the adenovirus 7-simian virus 40 genome had been transferred to an adenovirus 2 capsid.
منابع مشابه
Components of adenovirus-simian virus 40 hybrid viruses.
The DNA and protein components of the adenovirus 7-simian virus (SV)40 hybrid virus "E46(+)" have been investigated. The Ad.7-SV40 hybrid DNA genome could be distinguished from nonhybrid Ad. 7 genome on the basis of its molecular weight in an alkaline sucrose gradient. The hybrid genome could also be separated from nonhybrid adenovirus 2 DNA when purified transcapsidant adenovirus 2(+t7) (Ad.7-...
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ورودعنوان ژورنال:
- Journal of virology
دوره 5 3 شماره
صفحات -
تاریخ انتشار 1970